[10000ダウンロード済み√] u18666a solubility 267883

Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

UA and second to examine detergent solubility of ubiquitylated FlagNPC1 UA is a sterol derivative that has been shown to induce an NPClike phenotype (Ko et al, 01) To see whether this compound affected FlagNPC1 ubiquitylation, transfected cells were incubated with 2 g/ml UA for 12 hours UA treatment at this concentration and duration causedHowever, UA does not impair 25hydroxycholesterolmediated regulation of these processes In addition, UA impedes the ability of LDLderived cholesterol to support the growth of CHO cells However, UA has only moderate effects on growth supported by nonlipoprotein cholesterol LDL binding, internalization, and lysosomal hydrolysis of LDLcholesteryl

U18666a solubility

U18666a solubility- It has been shown that the treatment with 3β2(diethylamino)ethoxy androst5en17one (UA) causes the accumulation of cholesterol and the cationindependent mannose 6phosphate receptor (CIMPR) in late endosomal/lysosomal compartments in BHK cells The present study reports on a study of the effect of UA on CIMPR distribution in more detail in HeLaSolubility ≥ 8 mg/mL (490 mM);

Effects Of Ua And Progesterone Treatment On Npc1 Expression In Download Scientific Diagram

Effects Of Ua And Progesterone Treatment On Npc1 Expression In Download Scientific Diagram

After 2 days, lysis of cells and PK digestion were performed Detergent solubility assayTruscott and Augusteyn, 1977;References Hall, AM, et al 03 Pigment Cell Res 16, 149 Kobayashi, T, et al 1998 Nature 392, 193

To manufacturer's instructions Treatment with UA was started 24 h post transfection For transfection of ScN2a cells with siRNA, Lipofectamine 00 (Invitrogen, Karlsruhe, Germany) was used Twenty nanomoles of NPC1 or ns siRNA was added for 24 h;Interestingly, exosomes secreted from UAtreated astrocytes contain higher levels of APP, APPCTFs, soluble APP, APP secretases and Aβ140 than exosomes secreted from control astrocytes Furthermore, we show that exosomes derived from UAtreated astrocytes can lead to neurodegeneration, which is attenuated by decreasing Aβ production or by neutralizing As cataracts developed due to treatment with UA, the concentration of lens watersoluble protein decreased and ureasoluble protein increased These changes are characteristic for many cataracts (Pine, 1968;

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Plos One Late Endosomal Cholesterol Accumulation Leads To Impaired Intra Endosomal Trafficking

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Npc1 Regulates Er Contacts With Endocytic Organelles To Mediate Cholesterol Egress Nature Communications

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Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

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Cholesterol Accumulation By Macrophages Impairs Phagosome Maturation Journal Of Biological Chemistry

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Cholesterol Homeostasis In The Vertebrate Retina Biology And Pathobiology Journal Of Lipid Research

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Endosomal Lysosomal Cholesterol Sequestration By Ua Differentially Regulates Amyloid Precursor Protein App Metabolism In Normal And App Overexpressing Cells Molecular And Cellular Biology

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Npc Intracellular Cholesterol Transporter 1 Npc1 Mediated Cholesterol Export From Lysosomes Journal Of Biological Chemistry

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Late Endosomal Cholesterol Accumulation Leads To Impaired Intra Endosomal Trafficking

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Evidence For A Cholesterol Transport Pathway From Lysosomes To Endoplasmic Reticulum That Is Independent Of The Plasma Membrane Journal Of Biological Chemistry

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Plos One Late Endosomal Cholesterol Accumulation Leads To Impaired Intra Endosomal Trafficking

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Early Phase Redistribution Of The Cation Independent Mannose 6 Phosphate Receptor By Ua Treatment In Hela Cells Springerlink

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Characterization Of Fluorescent Sterol Binding To Purified Human Npc1 Journal Of Biological Chemistry

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Ua Alters The Detergent Solubility Of Gpi Anchored Proteins In Download Scientific Diagram

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The Intracellular Cholesterol Transport Inhibitor Ua Inhibits The Exosome Dependent Release Of Mature Hepatitis C Virus Journal Of Virology

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Cellular Mechanism Of Ua Mediated Apoptosis In Cultured Murine Cortical Neurons Bridging Niemann Pick Disease Type C And Alzheimer S Disease Sciencedirect

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U a Cholesterol Transport Inhibitor Cas 3039 71 2 Ab2698 Abcam

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Structural Basis For Itraconazole Mediated Npc1 Inhibition Nature Communications

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Plos One Late Endosomal Cholesterol Accumulation Leads To Impaired Intra Endosomal Trafficking

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1

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Automated Microscopy Screening For Compounds That Partially Revert Cholesterol Accumulation In Niemann Pick C Cells Journal Of Lipid Research

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Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

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Intracellular Accumulation Of Amyloidogenic Fragments Of Amyloid B Precursor Protein In Neurons With Niemann Pick Type C Defects Is Associated With Endosomal Abnormalities The American Journal Of Pathology

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Pdf Caveolin Targeting To Late Endosome Lysosomal Membranes Is Induced By Perturbations Of Lysosomal Ph And Cholesterol Content Semantic Scholar

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Effects Of Cholesterol Transport Inhibitor Ua On App Metabolism In Rat Primary Astrocytes Yang 17 Glia Wiley Online Library

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Endosomal Lysosomal Cholesterol Sequestration By Ua Differentially Regulates Amyloid Precursor Protein App Metabolism In Normal And App Overexpressing Cells Molecular And Cellular Biology

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Attenuation Of The Lysosomal Death Pathway By Lysosomal Cholesterol Accumulation Abstract Europe Pmc

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An Optical Nanoreporter Of Endolysosomal Lipid Accumulation Reveals Enduring Effects Of Diet On Hepatic Macrophages In Vivo

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Direct Perturbation Of Lens Membrane Structure May Contribute To Cataracts Caused By Ua An Oxidosqualene Cyclase Inhibitor Journal Of Lipid Research

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The Intracellular Cholesterol Transport Inhibitor Ua Inhibits The Exosome Dependent Release Of Mature Hepatitis C Virus Journal Of Virology

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Direct Perturbation Of Lens Membrane Structure May Contribute To Cataracts Caused By Ua An Oxidosqualene Cyclase Inhibitor Sciencedirect

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Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

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Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

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Cholesterol Accumulation By Macrophages Impairs Phagosome Maturation Journal Of Biological Chemistry

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The Intracellular Cholesterol Transport Inhibitor Ua Inhibits The Exosome Dependent Release Of Mature Hepatitis C Virus Journal Of Virology

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Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

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Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

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Effects Of Cholesterol Transport Inhibitor Ua On App Metabolism In Rat Primary Astrocytes Yang 17 Glia Wiley Online Library

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Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

Endosomal Lysosomal Cholesterol Sequestration By Ua Differentially Regulates Amyloid Precursor Protein App Metabolism In Normal And App Overexpressing Cells Molecular And Cellular Biology

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Golgi Localization And Phosphorylation Of Oxysterol Binding Protein In Niemann Pick C And Ua Treated Cells Journal Of Lipid Research

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Selective Aster Inhibitors Distinguish Vesicular And Nonvesicular Sterol Transport Mechanisms Pnas

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Early Phase Redistribution Of The Cation Independent Mannose 6 Phosphate Receptor By Ua Treatment In Hela Cells Springerlink

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Effects Of Cholesterol Transport Inhibitor Ua On App Metabolism In Rat Primary Astrocytes Yang 17 Glia Wiley Online Library

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Triazoles Inhibit Cholesterol Export From Lysosomes By Binding To Npc1 Pnas

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Effects Of Cholesterol Transport Inhibitor Ua On App Metabolism In Rat Primary Astrocytes Yang 17 Glia Wiley Online Library

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Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

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Mtorc1 Activates Srebp 2 By Suppressing Cholesterol Trafficking To Lysosomes In Mammalian Cells Pnas

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Ua Alters The Detergent Solubility Of Gpi Anchored Proteins In Download Scientific Diagram

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Selective Aster Inhibitors Distinguish Vesicular And Nonvesicular Sterol Transport Mechanisms Pnas

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Effects Of Ua On Cellular Levels Of Free Cholesterolgm1 And Download Scientific Diagram

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Differential Effects Of Sphingomyelin Hydrolysis And Cholesterol Transport On Oxysterol Binding Protein Phosphorylation And Golgi Localization Sciencedirect

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Niemann Pick C Disease And Mobilization Of Lysosomal Cholesterol By Cyclodextrin Journal Of Lipid Research

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Attenuation Of The Lysosomal Death Pathway By Lysosomal Cholesterol Accumulation Abstract Europe Pmc

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B Amyloid Inhibits Protein Prenylation And Induces Cholesterol Sequestration By Impairing Srebp 2 Cleavage Journal Of Neuroscience

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Role Of Cathepsin D In Ua Induced Neuronal Cell Death Journal Of Biological Chemistry

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A Trimeric Rab7 Gef Controls Npc1 Dependent Lysosomal Cholesterol Export Nature Communications

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Intracellular Cholesterol Transport And Compartmentation Journal Of Biological Chemistry

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Selective Aster Inhibitors Distinguish Vesicular And Nonvesicular Sterol Transport Mechanisms Pnas

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Gpnmb Gene And Protein Expression Are Increased In Macrophages Exposed To Ua

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Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

Identification Of Npc1 As The Target Of Ua An Inhibitor Of Lysosomal Cholesterol Export And Ebola Infection Elife

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

Endosomal Lysosomal Cholesterol Sequestration By Ua Differentially Regulates Amyloid Precursor Protein App Metabolism In Normal And App Overexpressing Cells Molecular And Cellular Biology

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

Ua An Intra Cellular Cholesterol Transport Inhibitor Inhibits Dengue Virus Entry And Replication Sciencedirect

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

Ua Cas 3039 71 2 Calbiochem 6615

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Lysosomal Integral Membrane Protein 2 Limp 2 Scarb2 Is Involved In Lysosomal Cholesterol Export Nature Communications

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Attenuation Of The Lysosomal Death Pathway By Lysosomal Cholesterol Accumulation The American Journal Of Pathology

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Ua Leads To An Enlargement Of Late Endosomes A Control And Download Scientific Diagram

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Endosomal Lysosomal Cholesterol Sequestration By Ua Differentially Regulates Amyloid Precursor Protein App Metabolism In Normal And App Overexpressing Cells Molecular And Cellular Biology

Evects Of Sandoz 58 035 Ua And Bawlomycin A1 On Lds Cytoplasmic Download Scientific Diagram

The Intracellular Cholesterol Transport Inhibitor Ua Inhibits The Exosome Dependent Release Of Mature Hepatitis C Virus Journal Of Virology

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Intracellular Distribution Of Tritc Lac B Cyd In Ua Treated Hepg2 Download Scientific Diagram

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Structural Basis For Human Sterol Isomerase In Cholesterol Biosynthesis And Multidrug Recognition Nature Communications

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The Intracellular Cholesterol Transport Inhibitor Ua Inhibits The Exosome Dependent Release Of Mature Hepatitis C Virus Journal Of Virology

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Ijms Free Full Text Secretory Npc2 Protein Mediated Free Cholesterol Levels Were Correlated With The Sorafenib Response In Hepatocellular Carcinoma Html

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Solubility Soluble in H2O Chemical Name (3S,8R,9S,10R,13S,14S)3(2(diethylamino)ethoxy)10,13dimethyl3,4,7,8,9,10,11,12,13,14,15,16dodecahydro1Hcyclopentaaphenanthren17(2H)one hydrochloride SDF Download SDF Canonical SMILESBiological Activity UA, a cell permeable drug, is a cholesterol synthesis and transport inhibitor Solubility * Preparing Stock Solutions * The above data is

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